Cannabinoids and the Brain

Molecular Biology, Pharmacology, Anatomy, and Physiology of the Endocannabinoid and Related Lipidergic Signaling Systems in the Brain.- An Historical Introduction to the Endocannabinoid and Endovanilloid Systems.- Biosynthesis of Anandamide and 2-Arachidonoylglycerol.- Removal of Endocannabinoids by the Body: Mechanisms and Therapeutic Possibilities.- Other Cannabimimetic Lipid Signaling Molecules.- CB1 Cannabinoid Receptors: Molecular Biology, Second Messenger Coupling and Polarized Trafficking in Neurons.- CB2 Cannabinoid Receptors: Molecular, Signaling, and Trafficking Properties.- CB1 and CB2 Receptor Pharmacology.- Functional Molecular Biology of the TRPV1 Ion Channel.- Alternative Interacting Sites and Novel Receptors for Cannabinoid Ligands.- Anatomical Distribution of Receptors, Ligands and Enzymes in the Brain and in the Spinal Cord: Circuitries and Neurochemistry.- Endocannabinoids at the Synapse: Retrograde Signaling and Presynaptic Plasticity in the Brain.- Endocannabinoid Functions in Neurogenesis, Neuronal Migration, and Specification.- The Endocannabinoid System in Clinical Neuroscience and Experimental Neuropsychiatry.- Cannabinoids in the Management of Nausea and Vomiting.- Endocannabinoids in Energy Homeostasis and Metabolic Disorders.- Cannabinoids and Neuroprotection.- Neuroinflammation and the Glial Endocannabinoid System.- Targeting Cannabinoid Receptors in Brain Tumors.- Cannabinoids for the Control of multiple Sclerosis.- Endocannabinoids in Alzheimer's Disease.- The Endocannabinoid System as a Therapeutic Target in Epilepsy.- The Endocannabinoid System in the Physiology and Pathology of the Basal Ganglia.- The Endocannabinoid System is a Major Player in Schizophrenia.- The Cannabinoid Controversy: Cannabinoid Agonists and Antagonists as Potential Novel Therapies for Mood Disorders.- Role of Cannabinoid Receptors in Anxiety Disorders.